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Designer Neural Networks with Embedded Semiconductor Microtube Arrays
Langmuir ( IF 3.9 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1021/acs.langmuir.7b03311
Aune Koitmäe 1, 2 , Manuel Müller 1, 2 , Cornelius S. Bausch 1 , Jann Harberts 1, 2 , Wolfgang Hansen 1, 2 , Gabriele Loers 3 , Robert H. Blick 1, 2
Affiliation  

Here we present a designer’s approach to building cellular neuronal networks based on a biocompatible negative photoresist with embedded coaxial feedthroughs made of semiconductor microtubes. The diameter of the microtubes is tailored and adjusted to the diameter of cerebellum axons having a diameter of 2–3 μm. The microtubes as well as the SU-8 layer serve as a topographical cue to the axons. Apart from the topographical guidance, we also employ chemical guidance cues enhancing neuron growth at designed spots. Therefore, the amino acid poly-l-lysine is printed in droplets of pl volume in the front of the tube entrances. Our artificial neuronal network has an extremely high yield of 85% of the somas settled at the desired locations. We complete this by basic patch-clamp measurements on single cells within the neuronal network.

中文翻译:

具有嵌入式半导体微管阵列的Designer神经网络

在这里,我们介绍了一种基于生物相容性负性光致抗蚀剂的嵌入式细胞神经元网络的设计方法,该负性光致抗蚀剂具有由半导体微管制成的嵌入式同轴引线。量身定制微管的直径,并将其调整为具有2–3μm直径的小脑轴突的直径。微管以及SU-8层可作为轴突的形貌线索。除了地形指导之外,我们还采用化学指导线索来增强设计点的神经元生长。因此,氨基酸的聚-赖氨酸印在试管入口前面的pl体积的液滴中。我们的人工神经元网络具有很高的产量,其中有85%的豆粕位于所需的位置。我们通过对神经元网络内单个细胞进行基本的膜片钳测量来完成此操作。
更新日期:2018-01-12
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