Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained attention recently as a potentially crucial layer of cancer cell regulation. lncRNAs are aberrantly expressed in a broad spectrum of cancers, and they play key roles in promoting and maintaining tumor initiation and progression, demonstrating their clinical potential as biomarkers and therapeutic targets. Recent discoveries have revealed that lncRNAs act as key signal transduction mediators in cancer signaling pathways by interacting with proteins, RNA, and lipids. Here, we review the mechanisms by which lncRNAs regulate cellular responses to extracellular signals and discuss their clinical potential as diagnostic indicators, stratification markers, and therapeutic targets of combinatorial treatments.

长的非编码RNA（lncRNA）由人类基因组的一个探索程度较小的区域编码，可能保留着缺少的癌症驱动程序，最近作为癌细胞调控的潜在关键层而受到关注。lncRNA在广泛的癌症中异常表达，它们在促进和维持肿瘤的发生和发展中起关键作用，证明其作为生物标志物和治疗靶标的临床潜力。最近的发现表明，lncRNA通过与蛋白质，RNA和脂质相互作用，在癌症信号传导途径中起关键信号转导介质的作用。在这里，我们回顾了lncRNA调节细胞对细胞外信号的反应的机制，并讨论了其作为诊断指标，分层标记，