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Interferonopathies in laboratory-negative suspected congenital infection
The Lancet Infectious Diseases ( IF 56.3 ) Pub Date : 2018-01-01 , DOI: 10.1016/s1473-3099(17)30700-4
Eva B Forman , Mary D King , Nicholas M Allen

We read Delan Devakumar and colleagues' Review1 of infectious causes of microcephaly with interest. This Review describes the major congenital infections that cause microcephaly and substantial neurological impairment worldwide, focusing on pathogenesis, diagnosis, and management. As the Review discusses congenital infection (with reference to pitfalls in diagnosis), it is also worth noting the interferonopathies, also called Aicardi-Goutières syndrome. The interferonopathies are a spectrum of disorders that should be considered in infants with suspected congenital infection and negative results in laboratory tests, including for cytomegalovirus, rubella, herpes simplex virus, toxoplasmosis, and Zika virus.

中文翻译:

实验室阴性可疑先天性感染的干扰素病

我们感兴趣地阅读了Delan Devakumar及其同事对小头畸形的感染原因的评论1。这篇综述描述了引起全球小头畸形和实质性神经系统损害的主要先天性感染,重点是发病机理,诊断和管理。正如本评论讨论先天性感染(参考诊断中的陷阱)一样,也值得注意的是干扰素病,也称为Aicardi-Goutières综合征。干扰素病是怀疑患有先天性感染且实验室检查结果阴性的婴儿应考虑的一系列疾病,包括巨细胞病毒,风疹,单纯疱疹病毒,弓形体病和寨卡病毒。
更新日期:2017-12-21
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