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Perfluoroalkyl acid levels in first-time mothers in relation to offspring weight gain and growth
Environment International ( IF 11.8 ) Pub Date : 2017-12-20 , DOI: 10.1016/j.envint.2017.12.002
Irina Gyllenhammar , Barbro Diderholm , Jan Gustafsson , Urs Berger , Peter Ridefelt , Jonathan P. Benskin , Sanna Lignell , Erik Lampa , Anders Glynn

We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the time of delivery are associated with birth outcome and if early life exposure (in utero/nursing) is associated with early childhood growth and weight gain. Maternal PFAA body burdens were estimated by analysis of serum samples from mothers living in Uppsala County, Sweden (POPUP), sampled three weeks after delivery between 1996 and 2011. Data on child length and weight were collected from medical records and converted into standard deviation scores (SDS). Multiple linear regression models with appropriate covariates were used to analyze associations between maternal PFAA levels and birth outcomes (n = 381). After birth Generalized Least Squares models were used to analyze associations between maternal PFAA and child growth (n = 200). Inverse associations were found between maternal levels of perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA), and birth weight SDS with a change of − 0.10 to − 0.18 weight SDS for an inter-quartile range (IQR) increase in ng/g PFAA. After birth, weight and length SDS were not significantly associated with maternal PFAA. However, BMI SDS was significantly associated with PFOA, PFNA, and PFHxS at 3 and 4 years of age, and with PFOS at 4 and 5 years of age. If causal, these associations suggest that PFAA affects fetal and childhood body development in different directions.



中文翻译:

初生母亲的全氟烷基酸水平与后代体重增加和生长的关系

我们调查了分娩时孕妇的全氟烷基酸(PFAAs)负担是否与出生结局有关,以及早期生命暴露(子宫内/哺乳期)是否与儿童早期成长和体重增加有关。母体PFAA的身体负担是通过分析生活在瑞典乌普萨拉县(POPUP)的母亲的血清样本(在1996年至2011年分娩后三周取样)估算的。儿童体长和体重的数据是从医疗记录中收集的,并转换为标准差评分(SDS)。使用具有适当协变量的多元线性回归模型分析孕产妇PFAA水平与出生结局之间的关联(n = 381)。出生后使用广义最小二乘模型分析母亲PFAA与儿童成长之间的关联(n = 200)。母体全氟壬酸(PFNA),全氟癸酸(PFDA)和全氟十一烷酸(PFUnDA)的出生水平与出生体重SDS之间存在负相关关系,四分位数之间范围(IQR)的出生体重SDS变化为-0.10至-0.18重量)的ng / g PFAA的增加。出生后,体重和身高SDS与母亲PFAA没有显着相关。但是,BMI SDS在3岁和4岁时与PFOA,PFNA和PFHxS显着相关,在4岁和5岁时与PFOS显着相关。如果有因果关系,则这些关联表明PFAA在不同方向上影响胎儿和儿童的身体发育。四分位数间距(IQR)的18重量SDS的ng / g PFAA增加。出生后,体重和身高SDS与母亲PFAA没有显着相关。但是,BMI SDS在3岁和4岁时与PFOA,PFNA和PFHxS显着相关,在4岁和5岁时与PFOS显着相关。如果有因果关系,则这些关联表明PFAA在不同方向上影响胎儿和儿童的身体发育。四分位数间距(IQR)的18重量SDS的ng / g PFAA增加。出生后,体重和身高SDS与母亲PFAA没有显着相关。但是,BMI SDS在3岁和4岁时与PFOA,PFNA和PFHxS显着相关,在4岁和5岁时与PFOS显着相关。如果有因果关系,则这些关联表明PFAA在不同方向上影响胎儿和儿童的身体发育。

更新日期:2017-12-21
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