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Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-03-22 , DOI: 10.1002/mnfr.201700738
Cheng-Chung Li 1 , Chun Liu 1 , Maobin Fu 2 , Kang-Quan Hu 1 , Koichi Aizawa 1, 2 , Shingo Takahashi 2 , Suganuma Hiroyuki 2 , Junrui Cheng 1 , Johannes von Lintig 3 , Xiang-Dong Wang 1
Affiliation  

Beta‐carotene‐15,15′‐oxygenase (BCO1) and beta‐carotene‐9′,10′‐oxygenase (BCO2) metabolize lycopene to biologically active metabolites, which can ameliorate nonalcoholic fatty liver disease (NAFLD). We investigate the effects of tomato powder (TP containing substantial lycopene (2.3 mg/g)) on NAFLD development and gut microbiome in the absence of both BCO1 and BCO2 in mice.

中文翻译:

番茄粉通过恢复SIRT1活性和脂联素功能(独立于类胡萝卜素裂解酶)抑制小鼠潜在的肝脂肪变性和炎症。

β-胡萝卜素-15,15'-加氧酶(BCO1)和β-胡萝卜素-9',10'-加氧酶(BCO2)将番茄红素代谢为具有生物活性的代谢物,可改善非酒精性脂肪肝疾病(NAFLD)。我们调查了在小鼠中既没有BCO1也没有BCO2的情况下,番茄粉(含有大量番茄红素(2.3 mg / g)的TP)对NAFLD发育和肠道微生物组的影响。
更新日期:2018-03-22
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