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Three Sequential C–N Bond Formations: tert-Butyl Nitrite as a N1 Synthon in a Three Component Reaction Leading to Imidazo[1,2-a]quinolines and Imidazo[2,1-a]isoquinolines
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2018-01-08 00:00:00 , DOI: 10.1021/acs.joc.7b02815
Prasenjit Sau 1 , Amitava Rakshit 1 , Anju Modi 1 , Ahalya Behera 1 , Bhisma K. Patel 1
Affiliation  

tert-Butyl nitrite serves the dual role of an oxidant as well as a N1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. Herein, two sp2 C–H functionalizations of styrenes and one sp2 C–H functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential C–N bond formations.

中文翻译:

三个顺序的C–N键形成:亚硝酸丁酯作为N1合成子在三组分反应中导致咪唑并[1,2- a ]喹啉和咪唑并[2,1- a ]异喹啉

亚硝酸丁酯在涉及喹啉,异喹啉和苯乙烯的多组分反应中起氧化剂和N1合成子的双重作用。本文中,两个SP 2苯乙烯的C-H官能化和一个SP 2的喹啉和异喹啉的C-H官能化导致通过三个连续的C-N键的形成形成稠合的喹啉和异喹啉的。
更新日期:2018-01-08
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