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Simple and Green Strategy for the Synthesis of “Pathogen-Mimetic” [email protected] by Combination of Photoinduced RAFT and Bioinspired Dopamine Chemistry
ACS Macro Letters ( IF 5.8 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1021/acsmacrolett.7b00837
Ming Wen 1, 2 , Mengjie Liu 1, 2 , Wentao Xue 1, 2 , Kai Yang 1, 2 , Gaojian Chen 1, 2 , Weidong Zhang 1, 2
Affiliation  

Innate immune responses recognizing pathogen associated molecular patterns (PAMPs) play a crucial role in adaptive immunity. Toll-like receptors (TLRs) and C-type lectin receptors (CLRs) contribute to antigen capture, uptake, presentation and activation of immune responses. In this contribution, metal-free reversible addition–fragmentation chain transfer (RAFT) polymerization of N-3,4-dihydroxybenzenethyl methacrylamide (DMA) and 2-(methacrylamido) glucopyranose (MAG) under sunlight irradiation using 2-cyanoprop-2-yl-α-dithionaphthalate (CPDN) as iniferter agent, can be employed to fabricate the multivalent glycopolymer containing bioresponsive sugar group and multifunctional catechol functionalities. The polymerization behavior is investigated and it presents controlled features. Moreover, bioinspired dopamine chemistry can be successfully utilized to form in situ glycopolymer-coated gold nanoparticles (AuNPs) without the need of additional reducing reagent, design “pathogen-mimetic” glycoadjuvant recognized by both CLRs and TLRs. The synthetic glycoadjuvant is found to enhance the adjuvant activity as “infected signals” in vitro.

中文翻译:

结合光诱导 RAFT 和仿生多巴胺化学合成“病原体模拟物”的简单绿色策略

识别病原体相关分子模式 (PAMP) 的先天免疫反应在适应性免疫中起着至关重要的作用。Toll 样受体 (TLR) 和 C 型凝集素受体 (CLR) 有助于抗原捕获、摄取、呈递和激活免疫反应。在这项贡献中, N的无金属可逆加成-断裂链转移(RAFT)聚合-3,4-二羟基苯甲基丙烯酰胺 (DMA) 和 2-(甲基丙烯酰胺) 吡喃葡萄糖 (MAG) 在阳光照射下使用 2-氰基丙-2-基-α-二硫代萘二甲酸酯 (CPDN) 作为诱导剂,可用于制备多价糖聚合物含有生物响应糖基和多功能儿茶酚功能。研究了聚合行为并呈现受控特征。此外,受生物启发的多巴胺化学可以成功地用于形成原位糖聚合物包覆的金纳米粒子 (AuNPs),而无需额外的还原剂,设计了 CLR 和 TLR 都能识别的“病原体模拟”糖佐剂。发现合成糖佐剂在体外作为“感染信号”增强佐剂活性。
更新日期:2017-12-20
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