Bisphenol S (BPS) has been introduced as a substitute for bisphenol A (BPA), and widely used in the manufacture of polycarbonate plastics, epoxy resins and thermal papers. Despite its adverse health outcomes and widespread exposure, pharmacokinetic data of BPS are not available for either animals or humans. The objective of the study is to describe pharmacokinetic characteristics of BPS in human body after a single oral administration with a compartmental pharmacokinetic model. Seven healthy young adults were orally exposed to 8.75 μg/bw of d₄-BPS, and serum and urine samples were collected for 48 h. The concentrations of total and unconjugated d₄-BPS in samples were measured using HPLC-MS/MS. Based on the time-concentration profiles in serum and urine, non-compartmental analysis was performed, and two-compartment model was constructed and validated. As a result of non-compartmental analysis, total d₄-BPS was rapidly absorbed within 1 h (0.7 ± 0.3 h) after oral administration, and excreted in urine with terminal half-life of < 7 h (6.8 ± 0.7 h). Fractional urinary excretion (F_ue) of total d₄-BPS for 48 h was 92 ± 17% (67–104%) for men and 70 ± 36% (59–77%) for women. The two-compartment model well described pharmacokinetic properties of BPS, and its parameter estimates were consistent with those from non-compartmental analysis. This study provides information on absorption, distribution, metabolism and elimination of BPS in human body, and the pharmacokinetic model can be utilized for estimating exposure dose of BPS, contributing to more realistic exposure assessment.

已引入双酚S（BPS）替代双酚A（BPA），并广泛用于制造聚碳酸酯塑料，环氧树脂和热敏纸。尽管其不利的健康结果和广泛的接触，但BPS的药代动力学数据尚不能用于动物或人类。该研究的目的是描述隔室药代动力学模型单次口服给药后人体中BPS的药代动力学特征。七名健康的年轻人经口暴露于8.75μg / bw的d ₄ -BPS，并收集了48小时的血清和尿液样本。总和未结合的浓度d ₄使用HPLC-MS / MS测量样品中的-BPS。基于血清和尿液中的时间浓度分布，进行非房室分析，并建立并验证了两室模型。作为非房室分析的结果，口服后1 h（0.7±0.3 h）内，总d ₄ -BPS迅速吸收，并在尿中排泄，终末半衰期<7 h（6.8±0.7 h）。尿总排泄分数（F _ue），共d ₄-男性48小时的BPS为92±17％（67–104％），女性为70±36％（59–77％）。两室模型很好地描述了BPS的药代动力学特性，其参数估计与非室分析的结果一致。这项研究提供了有关人体中BPS的吸收，分布，代谢和消除的信息，并且该药代动力学模型可用于估算BPS的暴露剂量，从而有助于更现实的暴露评估。