Obesity is associated with higher risks of developing diabetes and cardiovascular disease. Green tea, rich in polyphenolic compounds such as epigallocatechin gallate (EGCG) and epigallocatechin (EGC), has been shown to display anti-obesity effects. Houttuynia cordata leaves have also been shown to exhibit anti-obesity effects due to their chlorogenic acid content. Lactic acid bacteria are able to increase the production of polyphenolic compounds. This study aims to develop a novel anti-obesity fermentation product by combining H. cordata leaf tea with green tea, using Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101) for fermentation due to the advantages of bioconverting the polyphenolic compounds. The regulation of adipogenesis factors and the anti-obesity effect of the NTU 101-fermented tea were evaluated in an in vitro 3T3-L1 pre-adipocyte model and an in vivo obese rat model, respectively. The results show that the NTU 101-fermented tea, which contained higher EGCG, EGC, and chlorogenic acid levels than unfermented tea, was able to inhibit the lipogenesis of mature 3T3-L1 adipocytes by the stimulation of lipolysis. Furthermore, the body weight gain, body fat pad, and feeding efficiency of obese rats, induced with a high fat diet, were decreased by the oral administration of NTU 101-fermented tea. The significant anti-obesity effect was probably due to lipolysis. However, NTU 101 bacteria cells and EGCG may also act as functional ingredients to contribute to the anti-obesity effects of NTU 101-fermented products.

中文翻译：

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绿茶和鱼腥草叶的乳酸菌发酵产物具有抗脂肪和抗肥胖作用

肥胖与患糖尿病和心血管疾病的高风险有关。绿茶富含多酚化合物，如表没食子儿茶素没食子酸酯 (EGCG) 和表没食子儿茶素 (EGC)，已被证明具有抗肥胖作用。由于其绿原酸含量，鱼腥草叶也显示出抗肥胖作用。乳酸菌能够增加多酚化合物的产生。本研究旨在开发一种新型抗肥胖发酵产品，将 H. cordata 叶茶与绿茶结合，使用 Lactobacillus paracasei subsp。paracasei NTU 101 (NTU 101) 用于发酵，因为它具有生物转化多酚化合物的优点。分别在体外 3T3-L1 前脂肪细胞模型和体内肥胖大鼠模型中评估了 NTU 101 发酵茶对脂肪生成因子的调节和抗肥胖作用。结果表明，与未发酵茶相比，含有更高EGCG、EGC和绿原酸水平的NTU 101发酵茶能够通过刺激脂肪分解来抑制成熟3T3-L1脂肪细胞的脂肪生成。此外，口服 NTU 101 发酵茶可降低高脂饮食诱导的肥胖大鼠的体重增加、体脂垫和摄食效率。显着的抗肥胖作用可能是由于脂肪分解。然而，NTU 101 细菌细胞和 EGCG 也可作为功能成分，有助于 NTU 101 发酵产品的抗肥胖作用。