A highly fluorescent water soluble spirobifluorene dye with a large Stokes shift: synthesis, characterization and bio-applications,Chemical Communications

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A highly fluorescent water soluble spirobifluorene dye with a large Stokes shift: synthesis, characterization and bio-applications
Chemical Communications ( IF 4.9 ) Pub Date : 2017-12-19 00:00:00 , DOI: 10.1039/c7cc08761f
Friederike Schlüter _{1,

2,

3,

4} , Kristina Riehemann _{2,

3,

4,

5} , Nermin Seda Kehr _{2,

3,

4,

5} , Silvio Quici _{6,

7,

8,

9} , Constantin G. Daniliuc _{1,

2,

3,

4} , Fabio Rizzo _{1,

2,

3,

4,

6}

Affiliation

The first water-soluble spirobifluorene derivative has been synthesized, which exhibits high fluorescence quantum yield and a large Stokes shift (>100 nm). Proteins induce changes in the emission color, allowing to reach the nanomolar detection limit. Cellular uptake and cytotoxicity studies in living cells revealed its biocompatibility, indicating potential application for live cell imaging.

中文翻译：

具有大斯托克斯位移的高荧光水溶性螺二芴染料：合成，表征和生物应用

已经合成了第一种水溶性螺二芴衍生物，其表现出高的荧光量子产率和大的斯托克斯位移（＞ 100nm）。蛋白质会引起发射颜色的变化，从而达到纳摩尔检测极限。在活细胞中的细胞摄取和细胞毒性研究显示了其生物相容性，表明其在活细胞成像中的潜在应用。

更新日期：2018-01-16

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