A convergent, nine-step (LLS), enantioselective synthesis of α-cyclopiazonic acid and related natural products is reported. The route features a) an enantioselective aziridination of an imine with a chiral sulfur ylide; b) a bioinspired (3+2)-cycloaddition of the aziridine onto an alkene; and c) installation of the acetyltetramic acid by an unprecedented tandem carbonylative lactamization/N-O cleavage of a bromoisoxazole.

中文翻译：

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使用硫叶立德对映体合成环戊二酸家族。

据报道，α-环吡嗪酸及其相关天然产物的聚合，九步（LLS）对映选择性合成。该路线的特征是：a）亚胺与手性硫叶立德的对映选择性叠氮化；b）将氮丙啶生物启发（3 + 2）-环加成到烯烃上；c）通过空前的串联式羰基内酰胺化/溴异恶唑的NO裂解来安装乙酰基四酸。