Calibrants based on synthetic dendrimers have been recently proposed as a versatile alternative to peptides and proteins for both MALDI and ESI mass spectrometry calibration. Because of their modular synthetic platform, dendrimer calibrants are particularly amenable to tailoring for specific applications. Utilizing this versatility, a set of dendrimers has been designed as an internal calibrant with a tailored mass defect to differentiate them from the majority of natural peptide analytes. This was achieved by incorporating a tris-iodinated aromatic core as an initiator for the dendrimer synthesis, thereby affording multiple calibration points (m/z range 600–2300) with an optimized mass-defect offset relative to all peptides composed of the 20 most common proteinogenic amino acids.

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最近提出了基于合成树状聚合物的校准物，作为MALDI和ESI质谱校准的肽和蛋白质的通用替代品。由于其模块化的合成平台，树状聚合物校准物特别适合于特定应用的定制。利用这种多功能性，已设计了一组树枝状聚合物作为内部校正剂，并具有量身定制的质量缺陷，可将其与大多数天然肽分析物区分开。这是通过将三碘化芳族核作为树状聚合物合成的引发剂而实现的，从而提供了多个校准点（m / z范围为600–2300），相对于由20种最常见的所有肽组成的肽段，具有最佳的质量缺陷补偿蛋白质氨基酸。

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