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Engineering Elastin-Like Polypeptide-Poly(ethylene glycol) Multiblock Physical Networks
Biomacromolecules ( IF 6.2 ) Pub Date : 2018-01-02 00:00:00 , DOI: 10.1021/acs.biomac.7b01424
Andreia Araújo 1 , Bradley D. Olsen 2 , Ana Vera Machado 1
Affiliation  

Hybrids of protein biopolymers and synthetic polymers are a promising new class of soft materials, as the advantages of each component can be complementary. A recombinant elastin-like polypeptide (ELP) was conjugated to poly(ethylene glycol) (PEG) by macromolecular coupling in solution to form multiblock ELP-PEG copolymers. The hydrated copolymer preserved the thermoresponsive properties from the ELP block and formed hydrogels with different transition temperatures depending on salt concentration. Small angle scattering indicates that the copolymer hydrogels form sphere-like aggregates with a “fuzzy” interface, while the films form a fractal network of nanoscale aggregates. The use of solutions with different salt concentrations to prepare the hydrogels was found to influence the transition temperature, the mechanical properties, and the size of the nanoscale structure of the hydrogel without changing the secondary structure of the ELP. The salt variation and the addition of a plasticizer also affected the nanoscale structure and the mechanical characteristics of the films.

中文翻译:

工程类弹性蛋白多肽-聚乙二醇多嵌段物理网络

蛋白质生物聚合物和合成聚合物的混合体是一类有前途的新型软材料,因为每种成分的优势可以互补。通过溶液中的大分子偶联将重组弹性蛋白样多肽(ELP)与聚(乙二醇)(PEG)偶联,以形成多嵌段ELP-PEG共聚物。水合共聚物保留了ELP嵌段的热响应特性,并根据盐浓度以不同的转变温度形成了水凝胶。小角度散射表明共聚物水凝胶形成具有“模糊”界面的球形聚集体,而薄膜形成了纳米聚集体的分形网络。发现使用不同盐浓度的溶液制备水凝胶会影响转变温度,机械性能,和水凝胶的纳米级结构尺寸,而不会改变ELP的二级结构。盐的变化和增塑剂的添加也影响了薄膜的纳米级结构和机械特性。
更新日期:2018-01-02
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