Amphiphilic random co-polymers, which form stable reverse micelle-type assemblies, have been designed and synthesized. We demonstrate that the reverse micelles, formed by these co-polymers are capable of selectively binding peptides through electrostatic interactions, indicating that these random polymers can self-organize into functionally selective materials. Moreover, these random co-polymers also enable the ordered co-crystallization of matrix and extract guest molecules, giving rise to substantial signal enhancements during MALDI-MS detection. Together, these observations represent an excellent example of how random polymers can self-assemble into ordered, functional materials.

中文翻译：

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用于选择性结合和检测肽的无规共聚物的自组装†

已经设计并合成了形成稳定的反胶束型组装体的两亲无规共聚物。我们证明了由这些共聚物形成的反胶束能够通过静电相互作用选择性地结合肽，表明这些无规聚合物可以自组织成功能选择性的材料。此外，这些无规共聚物还可以实现基质和萃取物客体分子的有序共结晶，从而在MALDI-MS检测过程中产生明显的信号增强。总之，这些观察结果很好地说明了无规聚合物如何自组装成有序的功能材料。