Due to the high production volume, wide industrial applications, and environmental persistence, chlorinated paraffins (CPs) have been observed in various environmental matrices. However, data are scarce regarding human exposure to CPs. In this study, 54 human placentas were collected and analyzed by gas chromatography quadrupole time-of-flight mass spectrometry (GC-QTOF-HRMS). Short-chain CPs (SCCPs) were detected in all samples, with the concentrations ranging from 98.5 to 3771 ng/g lw (lipid weight). Medium-chain CPs (MCCPs) were detected in 38 of the samples, with the concentrations being in the range from 80.8 to 954 ng/g lw. SCCPs with 6–7 chlorines were predominant in human placentas and were mostly within the 10–11 carbon chain groups. In most samples, C₁₅H₂₅Cl₇ were found to be the most abundant MCCP congener groups. Pearson correlation analysis indicated that there was a significant positive correlation between the ΣSCCPs and ΣMCCPs concentrations in the placenta samples, whereas the concentrations of the ΣSCCPs/ΣMCCPs had no significant correlations with the gravida’s age, weight, or the lipid contents of placenta. To the best of our knowledge, this report describes the first investigation of CPs in the human placenta, which provides data for future evaluation of human exposure to CPs.

中文翻译：

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河南省人类胎盘中氯化石蜡的分布和分布特征

由于高产量，广泛的工业应用和环境持久性，已在各种环境基质中观察到氯化石蜡（CPs）。然而，关于人类接触CPs的数据很少。在这项研究中，收集了54个人类胎盘，并通过气相色谱四极杆飞行时间质谱（GC-QTOF-HRMS）进行了分析。在所有样品中均检测到短链CP（SCCP），浓度范围为98.5至3771 ng / g lw（脂质重量）。在38个样品中检测到中链CP（MCCP），浓度范围为80.8至954 ng / g lw。含6-7个氯的短链氯化石蜡在人胎盘中占主导地位，且大多在10-11个碳链组内。在大多数样品中，C ₁₅ H ₂₅ Cl ₇被发现是最丰富的MCCP同族群。皮尔森相关分析表明，胎盘样品中ΣSCCPs和ΣMCCPs之间存在显着正相关，而ΣSCCPs/ΣMCCPs的浓度与胎盘的年龄，体重或胎盘脂质含量无显着相关性。据我们所知，本报告描述了人类胎盘中CP的首次调查，该数据为将来评估人类接触CP的数据提供了依据。