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Magnetofluorescent Carbon Quantum Dot Decorated Multiwalled Carbon Nanotubes for Dual-Modal Targeted Imaging in Chemo-Photothermal Synergistic Therapy
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00531
Ming Zhang 1, 2 , Wentao Wang 3 , Yingjun Cui 2 , Ninglin Zhou 1, 4 , Jian Shen 1
Affiliation  

Magnetofluorescent nanoparticles with diagnostic and therapeutic functions show great promise in nanomedicine. Here, we report the magnetofluorescent carbon nanotubes (CNTs)/doxorubicin (DOX) nanocomposites and their functions act in synergetic chemo-photothermal synergistic therapy (Chemo/PTT) in cancer excision. Magnetofluorescent CNTs conjugated with a folic acid ([email protected]) were targets for dual-modal fluorescence (FL)/magnetic resonance (MR) imaging. Experiments in vitro and in vivo identified [email protected] with low toxicity, and good biocompatibility. Moreover, [email protected] whose release can be fostered by pH and NIR light dual-stimuli had been proved to be available for loading DOX. Following nuclear translocations, [email protected] were engineered to deliver DOX that targeted the nuclei. In vivo experiment indicates that the Chemo/PTT, as compared with the respective single treatment, can significantly control tumor growth. In addition, Chemo/PTT was not shown to render any appreciable toxicity. These findings suggest that the [email protected]/DOX could function as a multifunctional platform for simultaneous FL/MR imaging, PTT therapy, and drug delivery.

中文翻译:

磁荧光碳量子点装饰多壁碳纳米管用于化学光热协同治疗中的双模靶成像。

具有诊断和治疗功能的磁荧光纳米颗粒在纳米医学中显示出巨大的希望。在这里,我们报告磁荧光碳纳米管(CNTs)/阿霉素(DOX)纳米复合材料及其功能在癌症切除中的协同化学光热协同治疗(Chemo / PTT)中起作用。与叶酸共轭的磁致发光碳纳米管([电子邮件保护])是双峰荧光(FL)/磁共振(MR)成像的目标。体外和体内实验确定[电子邮件保护]具有低毒性和良好的生物相容性。此外,已经证明可以通过pH和近红外双刺激促进其释放的[电子邮件保护]可用于装载DOX。核易位后,[电子邮件保护]被设计为传递针对核的DOX。体内实验表明,与相应的单药治疗相比,Chemo / PTT可以显着控制肿瘤的生长。此外,未显示化学/ PTT会产生任何明显的毒性。这些发现表明,[受电子邮件保护] / DOX可以用作同时进行FL / MR成像,PTT治疗和药物输送的多功能平台。
更新日期:2017-12-18
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