当前位置: X-MOL 学术Ultrason. Sonochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Morphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation: an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solution
Ultrasonics Sonochemistry ( IF 8.4 ) Pub Date : 2017-12-16 , DOI: 10.1016/j.ultsonch.2017.12.032
Reza Abazari , Ali Reza Mahjoub , Alexandra M.Z. Slawin , Cameron L. Carpenter-Warren

In this study, we have reported a biocompatible metal-organic framework (MOF) with ultra-high surface area, which we have shown to have uses as both a cancer treatment delivery system and for environmental applications. Using a sonochemical approach, highly flexible organic H3BTCTB and ditopic 4,4́-BPDC ligands, along with modulators of acetic acid and pyridine were combined to prepare a Zn(II)-based metal-organic framework, DUT-32, [Zn4O(BPDC)(BTCTB)4/3(DEF)39.7(H2O)11.3]. Powder X-ray diffraction (PXRD), field-emission scanning electron microscopy (FE-SEM), and Fourier transform infrared spectroscopy (FTIR) were used to characterize, the particle size, shape, and structure of the DUT-32. To show the effects of shape and size of DUT-32 micro/nano-structures on doxorubicin (DOX) drug release and amoxicillin (AMX) adsorption, time of sonication, initial reagent concentrations, irradiation frequency, and acetic acid to pyridine molar ratios were optimized. The drug-loaded DUT-32 was soaked in simulated body fluid (SBF) and the drug release ratio was monitored through release time to perform in vitro drug release test. A slow and sustained release was observed for DUT-32 micro/nano-structures, having a considerable drug loading capacity. At the pH values 7.4-4.5, various profiles of pH-responsive release were achieved. Also, the prepared DUT-32 micro/nano-structures are found to be biocompatible with PC3 (prostate cancer) and HeLa (cervical cancer) cell lines, when tested by MTT assay. Moreover, DUT-32 micro/nano-structures were studied to show AMX adsorption from aqueous solution. Finally, kinetic studies indicated that AMX adsorption and drug release of DOX via this MOF are of first-order kinetics.



中文翻译:

超声辐照下金属有机骨架的形貌和尺寸控制合成:pH响应性抗癌药物释放的有效载体及其在水溶液中吸附阿莫西林的适用性

在这项研究中,我们报告了具有超高表面积的生物相容性金属有机骨架(MOF),我们已证明其既可以用作癌症治疗传递系统,又可以用于环境应用。使用声化学方法,将高度灵活的有机H 3 BTCTB和对位4,4′-BPDC配体,以及乙酸和吡啶的调节剂组合在一起,以制备基于Zn(II)的金属-有机骨架DUT-32,[Zn 4 O(BPDC)(BTCTB)4/3(DEF)39.7(H 2 O)11.3]。粉末X射线衍射(PXRD),场发射扫描电子显微镜(FE-SEM)和傅立叶变换红外光谱(FTIR)用来表征DUT-32的粒径,形状和结构。为了显示DUT-32微观/纳米结构的形状和尺寸对阿霉素(DOX)药物释放和阿莫西林(AMX)吸附的影响,超声处理的时间,初始试剂浓度,照射频率以及乙酸与吡啶的摩尔比为优化。将载有药物的DUT-32浸泡在模拟体液(SBF)中,并通过释放时间监测药物释放率,以进行体外药物释放测试。对于DUT-32微米/纳米结构,观察到缓慢而持续的释放,具有相当大的载药量。在pH值7.4-4.5时,获得了各种pH响应释放曲线。同样,当通过MTT测定法测试时,发现制备的DUT-32微/纳米结构与PC3(前列腺癌)和HeLa(宫颈癌)细胞系具有生物相容性。此外,研究了DUT-32的微/纳米结构以显示AMX从水溶液中的吸附。最终,动力学研究表明,通过该MOF对AMX的吸附和DOX的药物释放具有一级动力学。

更新日期:2017-12-18
down
wechat
bug