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Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration
Advanced Drug Delivery Reviews ( IF 16.1 ) Pub Date : 2017-12-17 , DOI: 10.1016/j.addr.2017.12.012
Biranche Tandon , Adrián Magaz , Richard Balint , Jonny J. Blaker , Sarah H. Cartmell

Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment. This review focuses on current state-of-the-art research in electroactive-based materials towards the delivery of drugs and other therapeutic signalling agents for wound care treatment. Future directions and current challenges for developing effective electroactive approach based therapies for wound care are discussed.



中文翻译:

电活性生物材料:用于控制药物输送和组织再生的控制药物输送的载体

用于刺激生物化学剂(例如基因,蛋白质和RNA分子)的电刺激在控制治疗的传递和促进组织再生方面具有巨大的潜力。电活性生物材料具有以局部,受控,响应和有效的方式递送这些试剂的能力。这些系统还结合了物理和生化线索的传递,并且可以通过建立对微环境的控制来进行编程,以实现对愈合的增强效果。这篇综述集中在基于电活性材料的当前最先进的研究上,以用于伤口护理治疗的药物和其他治疗性信号传递剂的输送。

更新日期:2017-12-17
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