Inorganic bioactive nanomaterials play a significant role in biomedical fields due to their excellent biocompatibility. AIEgen-functionalised mesoporous bioactive glass (FMBG) nanoparticles with sizes of 60–100 nm are prepared by post-grafting tetraphenylethene onto bioactive glass. The obtained nanoparticles emit strong blue light at 482 nm upon UV irradiation, showing potential application in cell imaging. Furthermore, the FMBG, with a high DOX loading capacity of 250.74 μg mg⁻¹ and good degradability in an acid environment, can be used for cancer treatment. The degradability of FMBG increases the release efficiency of DOX in the acid environment. The as-prepared hybrid nanoparticles may act as a promising drug delivery system due to their high drug loading capacity, pH sensitivity, good biodegradability, and biocompatibility.

中文翻译：

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可生物降解的AIEgen功能化介孔生物活性玻璃纳米颗粒，用于药物输送和细胞成像†

无机生物活性纳米材料由于其出色的生物相容性，在生物医学领域起着重要作用。AIEgen功能化的介孔生物活性玻璃（FMBG）纳米粒子的尺寸为60–100 nm，是通过将四苯基乙烯后接枝到生物活性玻璃上而制备的。所获得的纳米粒子在紫外线照射下会在482 nm处发出强烈的蓝光，显示出在细胞成像中的潜在应用。此外，具有250.74μgmg ^-1的高DOX负载能力的FMBG并且在酸性环境中具有良好的降解性，可用于癌症治疗。FMBG的可降解性提高了酸性环境中DOX的释放效率。如此制备的杂化纳米颗粒由于其高的载药量，pH敏感性，良好的生物降解性和生物相容性而可以用作有前途的药物递送系统。