A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.

中文翻译：

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基于由磁场激活的 DNAzyme 功能化磁性纳米粒子的纳米反应器†

提出了一种新的仿生纳米反应器设计 MaBiDz，其基于共聚物刷与超顺磁性纳米颗粒的结合。这种细胞纳米反应器具有两种磁性颗粒，每种磁性颗粒都具有二元脱氧核酶系统的两种成分。在目标 mRNA 分析物和磁场存在的情况下，纳米反应器组装形成由聚合物刷封闭的生物室，使二元脱氧核酶的催化功能具有增强的动力学。MaBiDz 在这里被证明是一种细胞传感器，用于快速检测和成像转移性乳腺癌的靶 mRNA 生物标志物，其功能显示出扩展为仿生细胞器的潜力，可以下调靶 mRNA 生物标志物的活性。