Coordination-driven self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon,Chemical Communications

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Coordination-driven self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon
Chemical Communications ( IF 4.9 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1039/c7cc07622c
Zhizhou Yue _{1,

2,

3,

4} , Han Wang _{1,

2,

3,

4} , Yiming Li _{4,

5,

6,

7,

8} , Yi Qin _{5,

9,

10,

11} , Lin Xu _{5,

9,

10,

11} , David J. Bowers _{1,

2,

3,

4} , Mahinda Gangoda _{1,

2,

3,

4} , Xiaopeng Li _{4,

5,

6,

7,

8} , Hai-Bo Yang _{5,

9,

10,

11} , Yao-Rong Zheng _{1,

2,

3,

4}

Affiliation

This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(IV) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

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