Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data.,The Lancet

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Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data.
The Lancet ( IF 168.9 ) Pub Date : 2018-01-01 , DOI: 10.1016/s1474-4422(17)30407-6
Bruce C V Campbell ₁ , Wim H van Zwam ₂ , Mayank Goyal ₃ , Bijoy K Menon ₃ , Diederik W J Dippel ₄ , Andrew M Demchuk ₃ , Serge Bracard ₅ , Philip White ₆ , Antoni Dávalos ₇ , Charles B L M Majoie ₈ , Aad van der Lugt ₉ , Gary A Ford ₁₀ , Natalia Pérez de la Ossa ₇ , Michael Kelly ₁₁ , Romain Bourcier ₁₂ , Geoffrey A Donnan ₁₃ , Yvo B W E M Roos ₁₄ , Oh Young Bang ₁₅ , Raul G Nogueira ₁₆ , Thomas G Devlin ₁₇ , Lucie A van den Berg ₁₄ , Frédéric Clarençon ₁₈ , Paul Burns ₁₉ , Jeffrey Carpenter ₂₀ , Olvert A Berkhemer ₂₁ , Dileep R Yavagal ₂₂ , Vitor Mendes Pereira ₂₃ , Xavier Ducrocq ₂₄ , Anand Dixit ₆ , Helena Quesada ₂₅ , Jonathan Epstein ₂₆ , Stephen M Davis ₁ , Olav Jansen ₂₇ , Marta Rubiera ₂₈ , Xabier Urra ₂₉ , Emilien Micard ₃₀ , Hester F Lingsma ₃₁ , Olivier Naggara ₃₂ , Scott Brown ₃₃ , Francis Guillemin ₂₆ , Keith W Muir ₃₄ , Robert J van Oostenbrugge ₃₅ , Jeffrey L Saver ₃₆ , Tudor G Jovin ₃₇ , Michael D Hill ₃ , Peter J Mitchell ₃₈ ,

Affiliation

Department of Medicine and Neurology, Melbourne Brain Centre, University of Melbourne, Parkville, VIC, Australia.
Department of Radiology, Maastricht University Medical Center and Cardiovascular Research Institute (CARIM), Maastricht, Netherlands.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Foothills Hospital, Calgary AB, Canada.
Department of Neurology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Department of Diagnostic and Interventional Neuroradiology, INSERM U 947, University of Lorraine and University Hospital of Nancy, Nancy, France.
Institute of Neuroscience, Newcastle University, Newcastle-upon-Tyne, UK.
Department of Neuroscience, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain.
Department of Radiology, Academic Medical Center, Amsterdam, Netherlands.
Department of Radiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Division of Medical Sciences, University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Department of Medical Imaging, University of Saskatchewan, Saskatoon, SK, Canada.
Department of Neuroradiology, University and University Hospital of Nantes, Nantes, France.
Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
Department of Neurology, Academic Medical Center, Amsterdam, Netherlands.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
The Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Department of Neurology, University of Tennessee College of Medicine, Chattanooga, TN, USA.
Department of Neuroradiology, Pitié-Salpêtrière Hospital and Paris Pierre et Marie Curie University, Paris, France.
Department of Neuroradiology, Royal Victoria Hospital, Belfast, UK.
Department of Radiology, West Virginia University Hospital, Morgantown, WV, USA.
Department of Neurology, Erasmus MC University Medical Center, Rotterdam, Netherlands; Department of Radiology, Erasmus MC University Medical Center, Rotterdam, Netherlands; Department of Radiology, Academic Medical Center, Amsterdam, Netherlands.
Department of Neurology and Neurosurgery, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, USA.
Division of Neuroradiology and Division of Neurosurgery, Departments of Medical Imaging and Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.
Department of Neurology, CHR Mercy, Metz, France.
Stroke Unit, Hospital de Bellvitge, Barcelona, Spain.
Clinical Investigation Centre-Clinical Epidemiology INSERM 1433, University of Lorraine and University Hospital of Nancy, Nancy, France.
Institute of Neuroradiology, Universitätsklinikum Kiel, Kiel, Germany.
Stroke Unit, Hospital Vall d'Hebron, Barcelona, Spain.
Stroke Unit, Hospital Clínic, Barcelona, Spain.
Clinical Investigation Centre-Innovative Technology INSERM 1433, University of Lorraine and University Hospital of Nancy, Nancy, France.
Department of Public Health, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Department of Neuroradiology, Sainte-Anne Hospital and Paris-Descartes University, INSERM U894, IMABRAIN, Neurosciences and Psychiatry Center, Paris, France.
Altair Biostatistics, St Louis Park, MN, USA.
Institute of Neuroscience & Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.
Department of Neurology, Maastricht University Medical Center and Cardiovascular Research Institute (CARIM), Maastricht, Netherlands.
Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Stroke Institute, Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Radiology, University of Melbourne, Parkville, VIC, Australia.

General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.

中文翻译：

全身麻醉对接受血管内血栓切除术与标准治疗的前循环缺血性卒中患者功能结果的影响：个体患者数据的荟萃分析。

在观察性研究中，与未接受 GA 治疗的患者相比，血管内血栓切除术期间的全身麻醉 (GA) 与更差的患者预后相关。我们评估了大血管前循环闭塞的缺血性卒中患者在 GA 下接受血管内血栓切除术、与非 GA 下血栓切除术（有或没有镇静剂）与标准治疗（即无血栓切除术）的功能结果，通过使用 GA 与标准治疗进行分层.

更新日期：2017-12-16

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