In the present work, an asymmetric copper‐catalyzed radical multi‐component cascade reaction of an unsaturated carboxylic acid, aryldiazonium tetrafluoroborate, and DABCO⋅(SO₂)₂ (DABSO) has been developed for the enantioselective synthesis of sulfonyl lactones. In this reaction, this SO₂ surrogate, DABSO was applied for the first time in the construction of chiral compounds. This multiple‐step asymmetric radical reaction was carried out under mild conditions and tolerated a wide range of substrates, resulting in the corresponding sulfonyl lactones with up to 95% chemical yields and 88% ee. The current reaction enriches the research contents of DABSO, and provides a new and efficient strategy to chiral functionalized lactones bearing quarternary stereogenic center.

中文翻译：

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铜催化DABCO⋅（SO2）不对称自由基反应合成手性磺酰基内酯

在目前的工作中，已经开发了不饱和羧酸，芳基重氮四氟硼酸酯和DABCO⋅（SO ₂）₂（DABSO）的不对称铜催化的自由基多组分级联反应，用于磺酰基内酯的对映选择性合成。在这个反应中，SO ₂作为替代，DABSO首次用于手性化合物的构建中。这种多步不对称自由基反应是在温和条件下进行的，可耐受多种底物，得到相应的磺酰基内酯，化学收率高达95％，ee高达88％。该反应丰富了DABSO的研究内容，为手性官能化的具有季生立体中心的内酯提供了新的有效策略。