In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.

中文翻译：

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疟原虫Peekaboo：PK4介导寄生虫潜伏期。

在本期《细胞宿主与微生物》一书中，Zhang等人。（2017）表明，PK4激酶活性介导的eIF2α磷酸化导致的翻译抑制在复发性疟疾感染中对青蒿素的耐药性中起关键作用。针对这种可药物化的过程可以延长当前一线治疗的寿命。