Diffusion coefficients are important in the design, optimization, and selection of membranes used in many applications including chemical and biosensors. Since the diffusion‐controlled transport of the analyte and interfering ions and molecules through polymer membranes may affect the rate of response, detection limit, selectivity, lifetime, etc. of chemical and biosensors, having a rapid and accurate method for the determination of diffusion coefficients of different compounds in a variety of membranes is uniquely important. In our contribution, we present a simple protocol for the rapid determination of the diffusion coefficients of electrochemically active analytes by linear sweep voltammetry. The expected errors in the estimated coefficients have been analyzed through modeling and the correlation between the magnitude of the unknown diffusion coefficients and the method's related maximum error is presented as a contour plot for different working electrode dimensions. It is also shown that our analysis protocol can be used to estimate the diffusion coefficient in complex membrane matrices and non‐ideal experimental conditions with a maximum systematic error of 14 % even without any experimental parameter optimization.

中文翻译：

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伏安法测定聚合物膜中的扩散系数：最小化误差的指南

扩散系数在设计，优化和选择包括化学和生物传感器在内的许多应用中使用的膜时很重要。由于分析物以及干扰离子和分子通过聚合物膜的扩散控制传输可能会影响化学和生物传感器的响应速度，检测限，选择性，寿命等，因此需要一种快速准确的方法来确定扩散系数在各种膜中分离不同化合物非常重要。在我们的贡献中，我们提出了一种简单的方案，可通过线性扫描伏安法快速测定电化学活性分析物的扩散系数。已通过建模分析了估计系数中的预期误差，并且未知扩散系数的大小与方法的相关最大误差之间的相关性以不同工作电极尺寸的等高线图的形式给出。还表明，即使没有任何实验参数优化，我们的分析方案也可用于估计在复杂膜基质和非理想实验条件下的扩散系数，最大系统误差为14％。