当前位置: X-MOL 学术Chem. Soc. Rev. › 论文详情
Chemical methods for mapping cysteine oxidation
Chemical Society Reviews ( IF 38.618 ) Pub Date : 2017-12-15 , DOI: 10.1039/C7CS00607A
Lisa J. Alcock, Michael V. Perkins, Justin M. Chalker

Cysteine residues in proteins are subject to diverse redox chemistry. Oxidation of cysteine to S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few prominent examples of these oxidative post-translational modifications. In living organisms, these modifications often play key roles in cell signalling and protein function, but a full account of this biochemistry is far from complete. It is therefore an important goal in chemical biology to identify what proteins are subjected to these modifications and understand their physiological function. This review provides an overview of these modifications, how they can be detected and quantified using chemical probes, and how this information provides insight into their role in biology. This survey also highlights future opportunities in the study of cysteine redox chemistry, the challenges that await chemists and biologists in this area of study, and how meeting such challenges might reveal valuable information for biomedical science.
更新日期:2018-01-02

 

Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
分享到
评论: 0
期刊列表
Wiley论文编辑服务,每月大奖送不停!
南京大学化学化工学院谢劲课题组招聘启事
广州大学水污染过程与控制研究团队招聘启事
华中师范大学第一届国际青年学者化学科学论坛
【问答】什么是“钻石烯”,它有哪些潜在应用前景?
X-MOL近期新增451种期刊(20171216)
2017年中科院JCR分区化学大类列表
试剂库存管理
化合物查询
down
wechat
bug