The development of biomaterials with high osteogenic ability for fast osteointegration with a host bone is of great interest. In this study, pearl/CaSO₄ composite scaffolds were fabricated using three-dimensional (3D) printing, followed by a hydration process. The pearl/CaSO₄ scaffolds showed uniform interconnected macropores (∼400 μm), high porosity (∼60%), and enhanced compressive strength. With CaSO₄ scaffolds as a control, the biological properties of the pearl/CaSO₄ scaffolds were evaluated in vitro and in vivo. The results showed that the pearl/CaSO₄ scaffolds possessed a good apatite-forming ability and stimulated the proliferation and differentiation of rat bone mesenchymal stem cells (rBMSCs), as well as giving a better expression of related osteogenic genes. Importantly, micro-computed tomography and histology of the critical-sized rabbit femoral condyle defects implanted with the scaffolds illustrated the osteogenic capacity of the pearl/CaSO₄ scaffolds. New bone was observed within 8 weeks. The bone-implant contact index was significantly higher for the pearl/CaSO₄ scaffolds implant than for the CaSO₄ scaffolds implant, indicating that the pearl/CaSO₄ scaffolds would be promising implants for bone regeneration.

中文翻译：

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珍珠/ CaSO ₄复合支架用于骨骼再生的 3D打印

具有高成骨能力以与宿主骨快速成骨的生物材料的开发引起了极大的兴趣。在这项研究中，珍珠/ CaSO ₄复合支架是使用三维（3D）打印，然后进行水合工艺制造的。珍珠/ CaSO ₄支架显示出均匀的互连大孔（〜400μm），高孔隙率（〜60％）和增强的抗压强度。以CaSO ₄支架为对照，在体外和体内评估了珍珠/ CaSO ₄支架的生物学特性。结果表明，珍珠/ CaSO ₄支架具有良好的磷灰石形成能力，可刺激大鼠骨间充质干细胞（rBMSCs）的增殖和分化，并能更好地表达相关的成骨基因。重要的是，植入支架的临界尺寸兔股骨con骨缺损的显微计算机断层扫描和组织学显示了Pearl / CaSO ₄支架的成骨能力。在8周内观察到了新骨。骨-植入物接触指数为珍珠显著更高/的CaSO ₄支架植入比所述的CaSO ₄的支架植入物，这表明珍珠/的CaSO ₄支架将被希望用于骨再生的植入物。