Activation of STAT3-coupled receptors along with TGF-β signaling are fundamental for Th17 cell differentiation both in vivo and in vitro. A recent paper shows that TGF-β signaling relieves SKI-mediated transcriptional repression of Rorc, the key regulator of the Th17 program.

中文翻译：

---

Th17大道上的新交通信号灯。

STAT3偶联受体的激活以及TGF-β信号传导对于体内和体外Th17细胞分化至关重要。最近的一篇论文表明，TGF-β信号传导可缓解SKI介导的Rorc（Th17程序的关键调控因子）的转录抑制。