Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's disease (PD) progression. Their findings reveal what could be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiopathic and familial cases, and suggest novel targets for therapeutic intervention.

中文翻译：

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通过培养皿中的人类多巴胺神经元窥视帕金森病的进展

Burbulla 及其同事的一项研究使用诱导的人类多巴胺 (DA) 神经元，证明了细胞功能障碍的毒性级联反应，这可能是帕金森病 (PD) 进展的基础。他们的发现揭示了从特发性和家族性病例中获得的人类神经元中多种致病途径之间的因果关系，并提出了治疗干预的新目标。