Fibrin, a natural hydrogel, is the end product of the physiological blood coagulation cascade and naturally involved in wound healing. Beyond its role in hemostasis, it acts as a local reservoir for growth factors and as a provisional matrix for invading cells that drive the regenerative process. Its unique intrinsic features do not only promote wound healing directly via modulation of cell behavior but it can also be fine-tuned to evolve into a delivery system for sustained release of therapeutic biomolecules, cells and gene vectors. To further augment tissue regeneration potential, current strategies exploit and modify the chemical and physical characteristics of fibrin to employ combined incorporation of several factors and their timed release. In this work we show advanced therapeutic approaches employing fibrin matrices in wound healing and cover the many possibilities fibrin offers to the field of regenerative medicine.

纤维蛋白是一种天然的水凝胶，是生理性凝血级联的最终产物，自然参与伤口愈合。除了止血作用外，它还充当生长因子的局部贮藏库，并作为驱动再生过程的入侵细胞的临时基质。其独特的内在特征不仅可以通过以下方式直接促进伤口愈合调节细胞行为，但也可以对其进行微调以发展成可持续释放治疗性生物分子，细胞和基因载体的递送系统。为了进一步增加组织再生的潜力，当前的策略利用和修饰血纤蛋白的化学和物理特性，以结合多种因素的结合和它们的定时释放。在这项工作中，我们展示了在伤口愈合中采用纤维蛋白基质的先进治疗方法，并涵盖了纤维蛋白为再生医学领域提供的多种可能性。