We investigated the effect of anodic treatment of titanium/tetrahedral amorphous carbon electrodes on the electrochemical detection of morphine and paracetamol. The anodic treatment caused both oxidation of the carbon and, more importantly, exposure and oxidation of the underlying Ti layer. This treatment anodically shifted the oxidation potential of paracetamol while that of morphine remained unaffected. The resulting electrode also showed better selectivity than a ta-C electrode without Ti. After anodic treatment at 2.5 V, selective detection of morphine with a physiologically meaningful detection limit of 9.8 nM and a linear range of 0.1–10 μM was obtained in the presence of 100 μM paracetamol.

我们研究了阳极处理钛/四面体无定形碳电极对吗啡和扑热息痛的电化学检测的影响。阳极处理既引起碳的氧化，更重要的是引起下面的Ti层的暴露和氧化。该处理阳极氧化对乙酰氨基酚的氧化电位，而吗啡的氧化电位不受影响。所得电极也显示出比没有Ti的ta-C电极更好的选择性。在2.5 V阳极处理后，在100μM对乙酰氨基酚存在下，选择性检测吗啡，其生理意义的检测限为9.8 nM，线性范围为0.1–10μM。