Bacterial and fungal pathogens involved in lung infection in cystic fibrosis patients utilize a particular family of glycan-binding proteins, characterized by the presentation of six fucose-binding sites on a ring-shaped scaffold. These lectins are attractive targets for anti-infectious compounds that could interfere in the recognition of host tissues by pathogens. The design of a cyclopeptide-based hexavalent structure allowed for the presentation of six fucose residues. The synthetic hexavalent compound displays liable geometry resulting in high-avidity binding by lectins from Aspergillus fumigatus and Burkholderia ambifaria. Replacing the fucose residue with a conformationally constrained fucomimetic does not alter the affinity and provides fine specificity with no binding to other fucose-specific lectins.

中文翻译：

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对新兴病原体的岩藻糖结合受体具有亲和力和选择性的多价糖代谢。

参与囊性纤维化患者肺部感染的细菌和真菌病原体利用特定的聚糖结合蛋白家族，其特征是在环状支架上存在六个岩藻糖结合位点。这些凝集素是抗感染化合物的诱人靶标，这些化合物可能会干扰病原体对宿主组织的识别。基于环肽的六价结构的设计允许呈现六个岩藻糖残基。合成的六价化合物显示出可靠的几何形状，可通过烟曲霉和冈比亚伯克霍尔德菌的凝集素产生高亲合力结合。用构象受限的烟熏模拟剂代替岩藻糖残基不会改变亲和力，并且提供了优良的特异性，并且不与其他岩藻糖特异性凝集素结合。