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The twilight of immunity: emerging concepts in aging of the immune system.
Nature Immunology ( IF 30.5 ) Pub Date : 2018-Jan-01 , DOI: 10.1038/s41590-017-0006-x
Janko Nikolich-Žugich

Immunosenescence is a series of age-related changes that affect the immune system and, with time, lead to increased vulnerability to infectious diseases. This Review addresses recent developments in the understanding of age-related changes that affect key components of immunity, including the effect of aging on cells of the (mostly adaptive) immune system, on soluble molecules that guide the maintenance and function of the immune system and on lymphoid organs that coordinate both the maintenance of lymphocytes and the initiation of immune responses. I further address the effect of the metagenome and exposome as key modifiers of immune-system aging and discuss a conceptual framework in which age-related changes in immunity might also affect the basic rules by which the immune system operates.

中文翻译:

免疫力的曙光:免疫系统老化的新兴概念。

免疫衰老是一系列与年龄有关的变化,这些变化会影响免疫系统,并随着时间的流逝而导致对传染病的脆弱性增加。本综述探讨了与年龄相关的变化的最新进展,这些变化影响免疫的关键组成部分,包括衰老对(主要是适应性)免疫系统细胞的影响,对指导免疫系统维持和功能的可溶性分子的影响,以及在淋巴器官上,它们协调淋巴细胞的维持和免疫反应的启动。我将进一步探讨作为免疫系统衰老关键调节因子的基因组和外来体的影响,并讨论一个概念框架,在该概念框架中,与年龄相关的免疫变化也可能影响免疫系统运作的基本规则。
更新日期:2017-12-15
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