当前位置: X-MOL 学术Biomater. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recent advancements in biocompatible inorganic nanoparticles towards biomedical applications
Biomaterials Science ( IF 6.6 ) Pub Date : 2017-12-14 00:00:00 , DOI: 10.1039/c7bm01020f
Mingxia Jiao 1, 2, 3, 4, 5 , Peisen Zhang 1, 2, 3, 4, 5 , Junli Meng 1, 2, 3, 4, 5 , Yingying Li 1, 2, 3, 4, 5 , Chunyan Liu 1, 2, 3, 4, 5 , Xiliang Luo 6, 7, 8, 9, 10 , Mingyuan Gao 1, 2, 3, 4, 5
Affiliation  

Due to their intrinsic physical properties potentially useful for imaging and therapy as well as their highly engineerable surface, biocompatible inorganic nanoparticles offer novel platforms to develop advanced diagnostic and therapeutic agents for improved detection and more efficacious treatment of major diseases. The in vivo application of inorganic nanoparticles was demonstrated more than two decades ago, however it turns out to be very complicated as nanomaterials exhibit much more sophisticated pharmacokinetic properties than conventional drugs. In this review, we first discuss the in vivo behavior of inorganic nanoparticles after systematic administration, including the basic requirements for nanoparticles to be used in vivo, the impact of the particles’ physicochemical properties on their pharmacokinetics, and the effects of the protein corona formed across the nano–bio interface. Next, we summarize the state-of-the-art of the preparation of biocompatible inorganic nanoparticles and bioconjugation strategies for obtaining target-specific nanoprobes. Then, the advancements in sensitive tumor imaging towards diagnosis and visualization of the abnormal signatures in the tumor microenvironment, together with recent studies on atherosclerosis imaging are highlighted. Finally, the future challenges and the potential for inorganic nanoparticles to be translated into clinical applications are discussed.

中文翻译:

生物相容性无机纳米粒子在生物医学应用中的最新进展

由于其固有的物理性质可能对成像和治疗有用,并且具有高度可工程化的表面,因此生物相容性无机纳米粒子为开发先进的诊断和治疗剂提供了新的平台,以改进对主要疾病的检测和更有效的治疗。该体内无机纳米粒子的应用被证明超过二十年前,但事实证明,纳米材料表现出比常规药物要复杂得多的药代动力学性质是非常复杂的。在这篇综述中,我们首先讨论了系统给药后无机纳米颗粒的体内行为,包括体内使用纳米颗粒的基本要求,颗粒的理化性质对其药代动力学的影响,以及在纳米生物界面上形成的蛋白质电晕的影响。接下来,我们总结了生物相容性无机纳米颗粒的制备和获得目标特异性纳米探针的生物缀合策略的最新技术。然后,突出了在肿瘤微环境中异常特征的诊断和可视化方面的敏感肿瘤成像方面的进展,以及对动脉粥样硬化成像的最新研究。最后,讨论了未来的挑战以及将无机纳米颗粒转化为临床应用的潜力。
更新日期:2017-12-14
down
wechat
bug