Objectives

To investigate the tubule occlusion and remineralization potential of a novel toothpaste with active tetracalcium phosphate/monetite mixtures under de/remineralization cycling.

Methods

Dentin de/remineralization cycling protocol consisted of demineralization in 1% citric acid at pH 4.6 with following remineralization with toothpastes and soaking in artificial saliva. Effectiveness of toothpastes to promote remineralization was evaluated by measurement of microhardness recovery, analysis of surface roughness, thickness of coating and scanning electron microscopy.

Results

The novel tetracalcium phosphate/monetite dentifrice had comparable remineralization potential as commercial calcium silicate/phosphate (SENSODYNE^®) and magnesium aluminum silicate (Colgate^®) toothpastes and significantly higher than control saliva (p < 0.02). Surface roughness was significantly lower after treatment with prepared and SENSODYNE^® dentifirice (p < 0.05). The coatings on dentin surfaces was significantly thicker after applying toothpastes as compared to negative control (p < 0.001).

Conclusions

The new fluoride toothpaste formulation with bioactive tetracalcium phosphate/monetite calcium phosphate mixture effectively occluded dentin tubules and showed good dentin remineralization potential under de/remineralization cycling. It could replace professional powder preparation based on this mixture. It was demonstrated that prepared dentifrice had comparable properties with commercial fluoride calcium silicate/phosphate or magnesium aluminum silicate dentifrices.

中文翻译：

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磷酸四钙/芒硝牙膏对牙本质再矿化和小管阻塞的影响

目标

为了研究在去矿化/再矿化循环下具有活性磷酸四钙/三氧化钛混合物的新型牙膏的小管阻塞和再矿化的潜力。

方法

牙本质脱矿/再矿化循环方案包括在pH 4.6的1％柠檬酸中进行矿化，然后再用牙膏矿化并浸泡在人工唾液中。通过测量显微硬度恢复，分析表面粗糙度，涂层厚度和扫描电子显微镜，评估了牙膏促进再矿化的有效性。

结果

新颖的磷酸四钙/斜磷钙石的洁齿剂具有相当的再矿化的潜力作为市售硅酸钙/磷酸盐（舒适达^®）和硅酸镁铝（高露洁^®）牙膏和比对照唾液（P <0.02）更高显著。用制得的和舒适达治疗后表面粗糙度为显著下^® dentifirice（P <0.05）。与阴性对照组相比，在使用牙膏后，牙本质表面的涂层明显增厚（p <0.001）。

结论

具有生物活性磷酸四钙/三水磷酸钙钙混合物的新型氟化物牙膏配方可有效封闭牙本质小管，并在去矿化/再矿化循环下显示出良好的牙本质再矿化潜力。它可以代替基于这种混合物的专业粉末制剂。已证明制备的洁牙剂具有与商业氟化硅酸钙/磷酸盐或硅酸铝镁洁牙剂相当的性能。