In this study, magnetic nanoparticles functionalized with carboxylated β-cyclodextrin (CM-β-CD; referred to Fe3 O4 @CM-β-CD) were synthesized and used for the efficient removal of cholesterol from milk and egg yolk via host-guest interactions. The results of Fourier-transform infrared, X-ray photoelectron spectroscopy, and thermogravimetric analysis indicated that the CM-β-CD was successfully conjugated to the surface of Fe3 O4 , and the amount of CM-β-CD attached on Fe3 O4 @CM-β-CD was determined to be 9.164%. The X-ray diffraction and transmission electron microscopy data revealed that the process of CM-β-CD coating did not result in a phase change of the Fe3 O4 , and the Fe3 O4 @CM-β-CD nanoparticles were determined to have an average size of about 15 nm. The results of isotherm adsorption and kinetic properties indicated that CM-β-CD functionalization increased the cholesterol removal efficiency, and the characteristics of cholesterol adsorption on Fe3 O4 @CM-β-CD were fitted well with the Langmuir adsorption model and Lagergren pseudo-1st-order kinetic models. Furthermore, compared with the Fe3 O4 nanoparticles, the functionalized Fe3 O4 @CM-β-CD nanoparticles exhibited greater cholesterol removal efficiency, and saponification of the milk and egg yolk was found to be beneficial for the cholesterol removal; using the Fe3 O4 @CM-β-CD nanoparticles, 98.8% and 94.6% of the cholesterol was extracted in 1 h from saponified milk and egg yolk, respectively, and the Fe3 O4 @CM-β-CD nanoparticles still displayed efficient cholesterol removal after 6 reuses.

中文翻译：

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用于高效去除胆固醇的功能磁性纳米颗粒

在这项研究中，合成了用羧化 β-环糊精（CM-β-CD；称为 Fe3 O4 @CM-β-CD）功能化的磁性纳米粒子，并用于通过主客体相互作用有效去除牛奶和蛋黄中的胆固醇. 傅里叶变换红外光谱、X 射线光电子能谱和热重分析结果表明，CM-β-CD 成功地与 Fe3 O4 表面共轭，并且附着在 Fe3 O4 @CM 上的 CM-β-CD 的数量-β-CD 被确定为 9.164%。X 射线衍射和透射电镜数据表明，CM-β-CD 涂层的过程没有导致 Fe3O4 的相变，并且 Fe3O4@CM-β-CD 纳米粒子被确定具有平均大小约 15 nm。等温线吸附和动力学性质的结果表明，CM-β-CD 功能化提高了胆固醇去除效率，胆固醇在 Fe3O4@CM-β-CD 上的吸附特征与 Langmuir 吸附模型和 Lagergren pseudo-1st 拟合良好。 - 阶动力学模型。此外，与Fe3O4纳米颗粒相比，功能化的Fe3O4@CM-β-CD纳米颗粒表现出更高的胆固醇去除效率，并且发现牛奶和蛋黄的皂化有利于去除胆固醇；使用 Fe3 O4 @CM-β-CD 纳米粒子，在 1 小时内分别从皂化牛奶和蛋黄中提取了 98.8% 和 94.6% 的胆固醇，并且 Fe3 O4 @CM-β-CD 纳米粒子仍然显示出有效的胆固醇去除6次重复使用后。