Can you tell the difference? Difference intensity analysis of fragment‐based screening by NMR 2D difference spectra enabled us to quickly discriminate potential chemical fragment hits from non‐hits, compounds inducing nonspecific NMR crosspeak broadening, and other nonspecific effects. This quantitative NMR spectral analysis method could assist in library screening and other applications in which NMR chemical‐shift perturbations are measured.

中文翻译：

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蛋白质检测核磁共振光谱法用于化学文库筛选的二维差异强度分析的开发和验证

你能说出区别吗？通过 NMR 二维差异光谱对基于片段的筛选进行差异强度分析，使我们能够快速区分潜在的化学片段命中与非命中、引起非特异性 NMR 交叉峰展宽的化合物以及其他非特异性效应。这种定量 NMR 光谱分析方法有助于图书馆筛选和其他测量 NMR 化学位移扰动的应用。