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Imaging Acute and Chronic Pain in the Human Brainstem and Spinal Cord
The Neuroscientist ( IF 5.6 ) Pub Date : 


While acute pain serves as a protective mechanism designed to warn an individual of potential or actual damaging stimuli, chronic pain provides no benefit and is now considered a disease in its own right. Since the advent of human brain imaging techniques, many investigations that have explored the central representation of acute and chronic pain have focused on changes in higher order brain regions. In contrast, far fewer have explored brainstem and spinal cord function, mainly due to significant technical difficulties. In this review, we present some of the recent human brain imaging studies that have specifically explored brainstem and spinal cord function during acute noxious stimuli and in individuals with chronic pain. We focus particularly on investigations that explore changes in areas that receive nociceptor afferents and compare humans and experimental animal data in an attempt to describe both microscopic and macroscopic changes associated with acute and chronic pain.



中文翻译:

对人脑干和脊髓的急性和慢性疼痛进行成像

急性疼痛是一种旨在警告个人潜在或实际伤害性刺激的保护性机制,而慢性疼痛则无济于事,现在被认为是一种疾病。自人类大脑成像技术问世以来,许多探索急性和慢性疼痛的主要表现方法的研究都集中在高阶大脑区域的变化上。相反,主要由于重大的技术困难,探索脑干和脊髓功能的人很少。在这篇综述中,我们介绍了一些近期的人类大脑成像研究,这些研究专门探讨了急性伤害性刺激和慢性疼痛患者的脑干和脊髓功能。

更新日期:2018-01-02
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