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From public health genomics to precision public health: a 20-year journey.
Genetics in Medicine ( IF 8.8 ) Pub Date : 2018-Jun-01 , DOI: 10.1038/gim.2017.211
Muin J Khoury 1 , M Scott Bowen 1 , Mindy Clyne 2 , W David Dotson 1 , Marta L Gwinn 3 , Ridgely Fisk Green 1 , Katherine Kolor 1 , Juan L Rodriguez 4 , Anja Wulf 1 , Wei Yu 1
Affiliation  

In this paper, we review the evolution of the field of public health genomics in the United States in the past two decades. Public health genomics focuses on effective and responsible translation of genomic science into population health benefits. We discuss the relationship of the field to the core public health functions and essential services, review its evidentiary foundation, and provide examples of current US public health priorities and applications. We cite examples of publications to illustrate how Genetics in Medicine reflected the evolution of the field. We also reflect on how public-health genomics is contributing to the emergence of "precision public health" with near-term opportunities offered by the US Precision Medicine (AllofUs) Initiative.

中文翻译:

从公共卫生基因组学到精准公共卫生:20 年历程。

在本文中,我们回顾了过去二十年来美国公共卫生基因组学领域的发展。公共卫生基因组学专注于将基因组科学有效和负责任地转化为人口健康益处。我们讨论了该领域与核心公共卫生职能和基本服务的关系,回顾了其证据基础,并提供了当前美国公共卫生优先事项和应用的示例。我们引用出版物的例子来说明医学遗传学如何反映该领域的发展。我们还通过美国精准医学 (AllofUs) 倡议提供的近期机会,反思公共卫生基因组学如何促进“精准公共卫生”的出现。
更新日期:2017-12-15
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