The prevalence of diabetes worldwide has been steadily increasing over the past 20 years. In 1997 it was estimated to be 124 million,¹ in 2015 it was estimated to be 415 million among 20–70 year olds, and this is expected to rise to 642 million by 2040.² In the UK, an estimated 4 million people have diabetes either diagnosed or undiagnosed.² This represents a significant burden on health care resources,³ particularly given that type 2 diabetes (T2D) is associated with comorbidities including obesity,⁴ cardiovascular disease,⁵ chronic kidney disease⁶ and neuropathy.⁷ T2D is a complex disorder, caused by a combination of environmental and genetic factors.⁸ Before the first genome-wide association study (GWAS) was conducted for T2D in 2007,⁹ very few genetic loci were known to be involved with T2D. However, linkage and candidate-gene association studies have often failed to replicate findings through lack of power and inadequate knowledge of the underlying biological pathways.^10,11

中文翻译：

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队列概况：苏格兰泰赛德的糖尿病遗传学审计和研究 (GoDARTS)

在过去的 20 年中，全球糖尿病的患病率一直在稳步上升。1997 年估计为 1.24 亿，¹ 2015 年 20-70 岁人群中估计为 4.15 亿，预计到 2040 年将增加到 6.42 亿^。2在英国，估计有 400 万人拥有糖尿病诊断或未诊断。²这对医疗保健资源构成重大负担，³特别是考虑到 2 型糖尿病 (T2D) 与包括肥胖、⁴心血管疾病、⁵慢性肾病⁶和神经病变在内的合并症有关。⁷T2D 是一种复杂的疾病，由环境和遗传因素共同引起。⁸在 2007 年针对 T2D 进行第一次全基因组关联研究 (GWAS) 之前，已知^{9 个}极少的基因位点与 T2D 相关。然而，连锁和候选基因关联研究由于缺乏能力和对潜在生物学途径的了解不足，往往无法复制研究结果。^{10 , 11}