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The Changing Face of Cardiac Inflammation
Circulation: Heart Failure ( IF 9.7 ) Pub Date : 2017-11-01 , DOI: 10.1161/circheartfailure.117.004528
Leslie T. Cooper 1
Affiliation  

See Articles by Berg et al and Müller et al

The search for noninvasive tests to diagnose myocardial inflammation has developed from the use of 67Gallium through antimyosin antibodies to the current standards of 18fluorodeoxyglucose positron emission tomography and cardiac magnetic resonance imaging (CMR).1,2 In CMR, a combination of 2 of 3 signal intensity measurements from native T2-weighted images and T1-weighted images obtained before and after gadolinium contrast provides a reasonable diagnostic performance with an estimated sensitivity of 67% and specificity of 91%.3 Since these original Lake Louise criteria were published, newer mapping techniques that quantify T1 and T2 relaxation times have significantly improved the performance of CMR for the diagnosis of inflammation.4

Early in the course of suspected myocarditis, CMR can predict meaningful clinical outcomes. In most but not all studies, the risk of ventricular arrhythmias is increased in patients with delayed gadolinium enhancement.57 CMR sequences that estimate extracellular volume and edema can also inform management decisions. For example, an increase in T2 relaxation time may suggest greater myocardial water content and a greater likelihood of improved cardiac function.8 Because exercise can trigger arrhythmias in the setting of acute myocarditis, current American Heart Association scientific and European Society of Cardiology position …



中文翻译:

不断变化的心脏炎症

参见Berg等人和Müller等人的文章

通过使用67镓通过抗肌球蛋白抗体,以目前的18氟脱氧葡萄糖正电子发射断层显像和心脏磁共振成像(CMR)的标准为基础,寻找可诊断心肌炎症的非侵入性测试方法。12在CMR,从天然T2加权图像和T1加权图像之前和之后的钆对比提供了67%的91%的估计的灵敏度和特异性的合理诊断性能得到2 3的信号强度测量的组合。3自从这些原始的路易斯湖准则发布以来,量化T1和T2弛豫时间的新型映射技术已大大改善了CMR诊断炎症的性能。4

在可疑心肌炎的早期,CMR可以预测有意义的临床结果。在大多数(但不是全部)研究中,delayed增强延迟的患者发生室性心律不齐的风险增加。5 - 7该估计细胞外体积和水肿也可以通知管理决策CMR序列。例如,T2弛豫时间的增加可能表明心肌水含量更高,心脏功能改善的可能性也更大。8由于运动会在急性心肌炎的情况下引发心律不齐,因此目前美国心脏协会科学和欧洲心脏病学会的立场...

更新日期:2017-12-14
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