An elevated prevalence of atypical handedness (left-, mixed-, or non-right-handedness) has been repeatedly reported in individuals with Autism Spectrum Disorder (ASD) compared to typically developing individuals. However, the exact magnitude of this difference as well as the presence of possible moderating factors remains unknown. Here, we present three sets of meta-analyses of studies that assessed the handedness prevalence among individuals with ASD, totaling 1199 individuals (n = 723 individuals with ASD and n = 476 typically developing individuals). Meta-analysis set 1 found that individuals with ASD are 3.48, 2.49, and 2.34 times more likely to be non-right-handed, left-handed, and mixed-handed compared to typically developing individuals, respectively. Meta-analysis set 2 found a 45.4%, 18.3%, and 36.1% prevalence of non-right-handedness, left-handedness, and mixed-handedness, respectively, amongst individuals with ASD. The classification of handedness, the instrument used to measure handedness, and the main purpose of the study were found to moderate the findings of meta-analysis set 2. Meta-analysis set 3 revealed a trend towards weaker handedness for individuals with ASD. The elevated levels of atypical handedness in individuals with ASD could be attributed to atypicalities in cerebral structure and lateralization for language in individuals with ASD.

中文翻译：

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自闭症中非典型性行为的水平升高：荟萃分析

与自闭症谱系障碍（ASD）的个体相比，与典型发展中的个体相比，非典型的习惯性（左撇子，混合撇子或非右撇子）患病率不断上升。但是，这种差异的确切大小以及可能的调节因素的存在仍然未知。在这里，我们提供了三组荟萃分析研究，评估了ASD个体中的惯常性患病率，总计1199例（n  = 723例ASD个体和n = 476个典型的发育中的个体）。荟萃分析集1发现，与典型发展中的个体相比，患有ASD的个体的非右撇子，左撇子和混合撇子的可能性分别高出3.48、2.49和2.34倍。荟萃分析2发现ASD个体中非右手习惯，左手习惯和混合习惯的患病率分别为45.4％，18.3％和36.1％。研究发现，惯用手的分类，用于测量惯用手的工具以及研究的主要目的是缓和荟萃分析集2的发现。荟萃分析集3揭示了ASD患者惯性较弱的趋势。