This meta-analysis summarizes research examining whether deficits in verbal learning are related to bilateral hippocampal volume reductions in patients with or at risk for schizophrenia and in healthy controls. 17 studies with 755 patients with schizophrenia (SCZ), 232 Genetic High Risk (GHR) subjects and 914 healthy controls (HC) were included. Pooled correlation coefficients were calculated between hemisphere (left, right or total) and type of recall (immediate or delayed) for each diagnostic group individually (SCZ, GHR and HC). In SCZ, left and right hippocampal volume positively correlated with immediate (r = 0.256, 0.230) and delayed (r = 0.132, 0.231) verbal recall. There was also a correlation between total hippocampal volume and delayed recall (r = 0.233). None of these correlations were significant in healthy controls. There was however, a positive correlation between left hippocampal volume and immediate recall in the GHR group (r = 0.356). The results suggest that hippocampal volume affects immediate and delayed verbal learning capacity in schizophrenia and provides further evidence of hippocampal dysfunction in the pathophysiology of schizophrenia.

这个元-分析总结了研究，考察精神分裂症患者或健康对照者的言语学习缺陷是否与双侧海马体积减少有关。包括755例精神分裂症（SCZ），232例遗传高危（GHR）受试者和914例健康对照（HC）的17项研究。针对每个诊断组（SCZ，GHR和HC）分别计算半球（左，右或总）和召回类型（立即或延迟）之间的合并相关系数。在SCZ中，左，右海马体积与即时口头回忆（r = 0.256，0.230）和延迟口头回忆（r = 0.132，0.231）正相关。海马总体积与延迟回忆之间也存在相关性（r = 0.233）。这些相关性在健康对照组中均无显着性。但是有 GHR组左海马体积与立即召回之间呈正相关（r = 0.356）。结果表明，海马体积影响精神分裂症的即时和延迟言语学习能力，并为精神分裂症的病理生理提供海马功能障碍的进一步证据。