The inhibitory tone that the cerebellum exerts on the primary motor cortex (M1) is known as cerebellar brain inhibition (CBI). Studies show CBI to be relevant to several motor functions, including adaptive motor learning and muscle control. CBI can be assessed noninvasively via transcranial magnetic stimulation (TMS) using a double-coil protocol. Variability in parameter choice and controversy surrounding the protocol’s ability to isolate the cerebellothalamocortical pathway casts doubt over its validity in neuroscience research. This justifies a systematic review of both the protocol, and its application. The following review examines studies using the double-coil protocol to assess CBI in healthy adults. Parameters and CBI in relation to task-based studies, other non-invasive protocols, over different muscles, and in clinical samples are reviewed. Of the 1398 studies identified, 24 met selection criteria. It was found that methodological design and selection of parameters in several studies may have reduced the validity of outcomes. Further systematic testing of CBI protocols is warranted, both from a parameter and task-based perspective.

小脑对初级运动皮层（M1）施加的抑制音称为小脑脑抑制（CBI）。研究表明，CBI与多种运动功能有关，包括自适应运动学习和肌肉控制。可以使用双线圈方案通过经颅磁刺激（TMS）对CBI进行无创评估。参数选择的可变性和围绕该协议隔离小脑皮质神经通路的能力的争议引起了人们对其在神经科学研究中有效性的怀疑。这证明对该协议及其应用进行系统的审查是合理的。以下评论检查了使用双线圈方案评估健康成人CBI的研究。与基于任务的研究，其他不同肌肉的其他非侵入性协议相关的参数和CBI，并在临床样本中进行审查。在确定的1398项研究中，有24项符合选择标准。发现在一些研究中进行方法学设计和参数选择可能降低了结果的有效性。从参数和基于任务的角度出发，都需要对CBI协议进行进一步的系统测试。