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Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2016-10-26 , DOI: 10.1016/j.neubiorev.2016.10.022
R.J.R. Blair , K. Veroude , J.K. Buitelaar

In this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent and its functional role/the symptom sets consequent on its dysfunction remain underspecified. However, dysfunctions in the other four neuro-cognitive systems are associated with symptom sets seen in individuals with conduct problems.



中文翻译:

神经认知系统功能障碍和症状集:对有行为问题的青年进行的fMRI研究的综述

在本文中,我们回顾了功能磁共振成像在神经认知系统上的工作,这些神经认知系统被认为在有行为问题的人(即行为障碍(CD),对立违抗性障碍(ODD)或反社会行为而没有正式临床诊断的人)中功能失调。它们是:同理心,急性威胁响应,基于增援的决策,响应抑制和默认模式网络。关于默认模式网络的证据有些不一致,并且其功能作用/功能障碍导致的症状集仍未明确。但是,其他四个神经认知系统的功能障碍与行为障碍患者出现的症状有关。

更新日期:2016-10-26
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