The translational value of preclinical research was recently enhanced by abnormal aggression models, which focus on deviant behaviors induced by the exposure of rodents to etiological factors of aggression-related psychopathologies. Prompted by similar trials in other psychiatric disorders, here we investigate models of abnormal aggression from the perspective of DSM5 criteria. After proposing principles based on which analogies can be established between psychopathology symptoms and rodent behavioral dysfunctions, we show that rodents submitted to abnormal aggression models fulfill basic criteria of aggression-related psychopathologies; moreover, some models can be considered specific to particular disorders e.g. conduct disorder. We also show that abnormal and species-typical aggressions differ in terms of both brain mechanisms and pharmacological responsiveness, which mimics differences observed in psychiatric disorders. We conclude that evaluating abnormal aggression models from a DSM5 perspective is not only possible but also worthwhile, and such models may contribute to the development of novel treatment strategies not only for aggression as a symptom but also for specific aggression-related disorders or multi-symptom clusters at least.

最近，异常攻击模型提高了临床前研究的翻译价值，该模型专注于将啮齿动物暴露于与攻击相关的精神病理学的病因引起的异常行为。在其他精神疾病中也有类似的试验提示，这里我们从DSM5标准的角度研究异常侵略模型。在提出了可以在心理病理学症状和啮齿动物行为功能障碍之间建立类比的原则之后，我们证明了提交给异常攻击模型的啮齿动物符合与攻击相关的精神病理学的基本标准；此外，可以将某些模型视为特定于特定疾病（例如行为障碍）的模型。我们还表明，在大脑机制和药理反应性方面，异常和典型的侵略行为都不同，这模仿了在精神疾病中观察到的差异。我们得出结论，从DSM5角度评估异常攻击模型不仅是可行的，而且值得，而且这种模型可能有助于开发新的治疗策略，不仅将攻击作为一种症状，而且还针对特定的与攻击相关的疾病或多症状至少集群。