Enantioselective Friedel–Crafts C2-alkylation reactions of 3-substituted indoles with trifluoropyruvates and cyclic N-sulfonyl α-ketiminoesters were developed by using the complexes of Cu(OTf)₂ or Zn(OTf)₂ with chiral bisoxazoline ligands. A range of chiral indole-containing trifluoromethylated α-hydroxyesters and cyclic α-aminoesters bearing quaternary stereogenic centers were afforded in good yields and excellent enantioselectivities (up to 99% ee) under mild conditions.

中文翻译：

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对映选择性的 Friedel–Crafts将三取代的吲哚与三氟丙酮酸酯和环状N-磺酰基α-酮亚氨基酸酯进行C2-烷基化反应†

通过使用Cu（OTf）₂或Zn（OTf）₂与手性双恶唑啉配体的配合物，开发了3-取代的吲哚与三氟丙酮酸和环状N-磺酰基α-酮亚氨基酸酯的对映选择性Friedel-Crafts C2-烷基化反应。在温和条件下，以良好的收率和优异的对映选择性（高达99％ee）提供了一系列带有季立体异构中心的手性含吲哚的三氟甲基化α-羟基酯和环状α-氨基酯。