Oxidative stress and its correlation with degenerative diseases have been attracting wide attention. In the present study, Lactobacillus plantarum (L. plantarum) CCFM10 and RS15-3 were examined for their abilities to resist oxidative stress in D-galactose (D-gal)-exposed mice. Both strains significantly reversed the changes of hepatic total antioxidant capacity, catalase activity and glutathione content induced by D-gal. The antioxidative abilities of CCFM10 were higher than those of RS15-3. Moreover, the composition of the mice microbiota was changed by D-gal injection, which was characterized by the up-regulated ratio of Firmicutes/Bacteroidetes. At the genus level, the relative abundance of Lactobacillus reduced and the proportion of one genus of Clostridiales increased. However, in probiotic groups, the composition of the microbiota was similar to that of the control group at the phylum and the genus levels, suggesting that probiotic administration can restore the microbiota. Our study suggests that the protective effects of L. plantarum strains on the host microbiota could be one of the mechanisms of their resistance to oxidative stress. Besides this, through comparing the antioxidative capacity of two strains, we also found that the antioxidative capacity of L. plantarum might be strain-specific.

中文翻译：

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植物乳杆菌CCFM10减轻d-半乳糖诱导的衰老小鼠的 氧化应激并恢复肠道菌群

氧化应激及其与退化性疾病的关系已引起广泛关注。在本研究中，植物乳杆菌（L. plantarum）CCFM10和RS15-3在D-半乳糖（D -gal）暴露的小鼠中抵抗氧化应激的能力得到了检验。两种菌株均显着逆转了由D -gal诱导的肝脏总抗氧化能力，过氧化氢酶活性和谷胱甘肽含量的变化。CCFM10的抗氧化能力高于RS15-3。此外，D改变了小鼠微生物群的组成。-gal注射，其特征是上皮菌/拟杆菌的比例上调。在属水平上，乳酸杆菌的相对丰度降低，梭菌的一个属的比例增加。但是，在益生菌组中，菌群的组成和属水平与对照组相似，这表明益生菌的施用可以恢复菌群。我们的研究表明，植物乳杆菌菌株对宿主菌群的保护作用可能是其抗氧化应激的机制之一。除此之外，通过比较两个菌株的抗氧化能力，我们还发现植物乳杆菌的抗氧化能力可能是菌株特异性的。