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Protein engineering: Finding the best ligase
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2017-12-12 , DOI: 10.1038/nchembio.2533
Christian F W Becker

Protein engineering: Finding the best ligase

Protein engineering: Finding the best ligase, Published online: 12 December 2017; doi:10.1038/nchembio.2533

Modification of folded proteins at will, within any sequence context, remains an elusive goal. A proteome-wide screening approach has now identified a set of protein ligases that enables conjugation of peptides to almost any protein N terminus, overcoming longstanding limitations in protein engineering.


中文翻译:

蛋白质工程:寻找最佳的连接酶

蛋白质工程:寻找最佳的连接酶

蛋白质工程:寻找最佳的连接酶,在线发布:2017年12月12日;doi:10.1038 / nchembio.2533

在任何序列范围内随意折叠蛋白质的修饰仍然是一个遥不可及的目标。全蛋白组筛选方法现已鉴定出一套蛋白质连接酶,可将肽与几乎任何蛋白质N末端缀合,克服了蛋白质工程领域的长期限制。
更新日期:2017-12-13
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