Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. These vesicles are likely essential for the membrane expansion that is required for nerve growth, and probably coordinate with rearrangement of the cytoskeletons. Such mechanisms are poorly understood from molecular and cell biological aspects. Recently, we used superresolution microscopic approaches and described new mechanisms that are involved in the interaction between the vesicles and F-actin in the leading edge of the peripheral domain. Vesicles mainly accumulate in the central domain of growth cones. However, the dynamics of vesicles in each domain, for example, clathrin dependency, are totally distinct from each other. Here, we discuss the diversity of the dynamics of vesicular and related proteins that play different roles in nerve growth.

生长锥是发育中的神经元中扩展神经元过程的高度运动性尖端，具有许多囊泡。这些囊泡可能是神经生长所需的膜扩张所必需的，并且可能与细胞骨架的重排协调。从分子和细胞生物学方面对此类机制了解甚少。最近，我们使用超分辨率显微镜方法，并描述了囊泡与F-肌动蛋白在外周结构域前沿之间的相互作用中所涉及的新机制。囊泡主要聚集在生长锥的中央区域。但是，每个域中囊泡的动力学（例如网格蛋白依赖性）彼此完全不同。这里，